This association is the simplest symbiotic system known to date and a unique model for studying mechanisms of interspecific relationships at the genomic and metabolic levels. hospitalis indicates that the relationship has impacted both genomes. Evidence of lateral gene exchange between N. CONCLUSIONS: A combination of genomic and cellular features suggests highly efficient adaptation to the low energy yield of sulfur-hydrogen respiration and efficient inorganic carbon and nitrogen assimilation. However, this process appears to be partially balanced by lateral gene transfer from archaeal and bacterial sources. A streamlined genome is also suggested by a low frequency of paralogs and fragmentation of many operons. hospitalis lineage has lost most of the genes associated with a heterotrophic metabolism that is characteristic of most of the Crenarchaeota. A comparative genomic reconstruction suggests that the I. hospitalis and found it to be the smallest among independent, free-living organisms. RESULTS: We sequenced the complete genome of I. Little is known about the mechanisms that enable this relationship. Keller, Martin Stetter, Karl O.īACKGROUND: The relationship between the hyperthermophiles Ignicoccus hospitalis and Nanoarchaeum equitans is the only known example of a specific association between two species of Archaea. Rachel, Reinhard Huber, Harald Eisen, Jonathan A. Anderson, Abraham Fernandes, Fillipe Szeto, Ernest Lapidus, Alla Kyrpides, NikosC. Chen, Wenqiong Deciu, Cosmin Hutchinson, Don Eads, Jonathan R. Lykidis, Athanasios Mavromatis, Konstantinos Podar, Mircea Hudson, Matthew E. Sun, Hui Anderson, Iain Makarova, Kira S. All rights reserved.Ī genomic analysis of the archael system Ignicoccus hospitalis-Nanoarchaeum equitansĮnergy Technology Data Exchange (ETDEWEB) Our study applies statistical and visualization techniques to a mixed-source omics dataset to yield a more global insight into a complex system, that was not readily discernable from separate omics studies. This multi-omics analysis builds upon previously identified cellular patterns while offering new insights into mechanisms that enable the I. We also identified differences in precursors linked to amino acid metabolism, NADH metabolism, and carbon fixation, providing new insights into the metabolic adaptions of I. equitans co-culture, which has been connected to the differential use of ribosomal subunits and was previously unnoticed. Analysis indicated an overall reduction in diversity of metabolic precursors in the I. Key findings of our multi-level omics analysis indicated that I. Enriched molecular pathways were subsequently visualized using interaction maps generated using STRING. hospitalis is grown alone or in co-culture with N. DAVID identified functionally-related groups enriched when I. We jointly analyzed multiple levels of omics datasets obtained from published, independent transcriptomics, proteomics, and metabolomics analyses. However, significant questions remain about the nature of the interactions between these archaea. Recent independently-conducted 'omics' analyses have generated insights into the molecular factors modulating this association. A model system for studying interspecies interactions is the marine hyperthermophiles Ignicoccus hospitalis and Nanoarchaeum equitans. Studies of interspecies interactions are inherently difficult due to the complex mechanisms which enable these relationships. Rawle, Rachel A Hamerly, Timothy Tripet, Brian P Giannone, Richard J Wurch, Louie Hettich, Robert L Podar, Mircea Copié, Valerie Bothner, Brian Multi-omics analysis provides insight to the Ignicoccus hospitalis-Nanoarchaeum equitans association. Méthode : il s'est agi d'une étude rétrospective et descriptive dans le service de cardiologie du Centre Hospitalier Universitaire Tokoin de Lomé. īut : Afin d'améliorer la prise en charge, d'éviter l'évolution rapide vers une insuffisance cardiaque réfractaire au traitement, nous avons entrepris cette étude en milieu hospitalier. La cardiomyopathie dilatee au centre hospitalier Universitaire.
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